Top 10 Hardest Bosses in Sci-Fi Games



These sci-fi baddies were an absolute chore to fight. Welcome to WatchMojo, and today we’re counting down our picks for the toughest boss battles that had a sci-fi flavor to them. Our countdown of the hardest bosses in Sci-Fi games includes Raven Beak from “Metroid Dread” (2021), Viper from “Titanfall 2” (2016), Yellow Devil from “Mega Man” (1987), Metal Gear Sahelanthropus from “Metal Gear Solid V: The Phantom Pain” (2015), and more! Did any of these bosses make you loathe all things sci-fi? Let us know in the comments!

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38 thoughts on “Top 10 Hardest Bosses in Sci-Fi Games”

  1. Ratchet and Clank: Up Your Arsenal – Dr. Nefarious is freaking hardcore that first run through. And he's technically not the final final boss, because you have to beat the giant robot thing after you beat him, but that's actually pretty easy, Nefarious is the hard part.

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  2. I still haven't beaten Laxasia in Lie Of P, GRRR!!! Essej in Control was really hard but finally got her ass lol 😂 I think the high level Apex Fireclaw was harder than the Apex Slaughterspine but both are very tough.

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  3. It's wild to me that on all of these lists include laxasia. I beat lies of p 6 times. 4 of those time I beat her first try. The other 2 took no more than 3 tries. Nameless puppet on the other hand. I couldn't beat him under 10 tries if my life depended on it lol

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  4. I'm sorry but the final boss of Remnant from the Ashes is extremely easy, you need to have enough healing items for the other dimension, kill all the enemies you can and when you return, each shot takes away thousands of points of his lifebar.

    PD: Sahelanthropus does have weak points, the white cylinders on its back.

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  5. 5. I never want to play early Mega Man games like this ever again as they were outdated by the standards of Mega Man 11. Back in the NES days, Capcom has no idea what good Mega Man difficulty balancing really means.
    4. Yoshio Sakamoto & his MercurySteam team must've made the finale of the Metroid timeline be the hardest 2D Metroid which make sense. Dread were only for fans who've played previous 2D Metroid before, not for anyone casual.
    2. WHY DO I HAVE TO BE REMINDED OF MGS5 AGAIN!? THE GAME BEING SO FUCKING INCOMPLETE WAS KONAMI'S BIGGEST MISTAKE THEY'VE EVER DONE THAT UNLESS THEIR PLANS FOR REDEMPTION OF METAL GEAR HAS PROVEN SUCCESSFUL, I WILL NEVER FORGIVE THAT COMPANY!

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  6. I've never played against the mega Man BS but the times I've seen it played against seem obnoxious I am glad I have never played and had to fight that thing I'd be seeing the game over screen way too often

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