The Ultimate Guide to Men's Hormones – TIER LIST (DHT is a trash hormone part VIII)

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Linked videos:
Team 3D Alpha tiered hormone video:
https://youtu.be/XCrHI-DpeRU?si=am9m8mvUZKLCkGmV
DHT trash hormone series:
https://youtu.be/Tzu_yWBR_rU
https://youtu.be/wRXZY-wY8b0
https://youtu.be/eSVhcp0jmKE
https://youtu.be/H_07OCa_1h4
https://youtu.be/nMWvPe5PQCg
https://youtu.be/UxcqZO3F6kA
https://youtu.be/MdmXIeH39FU
https://youtu.be/wRXZY-wY8b0
Neurosteroid series:
https://youtu.be/sHDdNR3MUeI
https://youtu.be/kkvxuqqRBOw
https://youtu.be/2hYqoY7kzi0
https://youtu.be/EkS6_wub7W8
https://youtu.be/EgYczERIkBg
Optimal dose of finasteride:
https://youtu.be/15PHO1m6D-c
Why going bald will ruin your life:
https://youtu.be/gxoj9jeizys
Finasteride in the young:
https://youtu.be/6zdK_YdE1nM
Finasteride and beard growth
https://youtu.be/MxxEKG1DEb8
5AR blockers and depression, anxiety:
https://youtu.be/1p5RD1Yd6jE
https://youtu.be/EgYczERIkBg
DHT and muscles
https://www.youtube.com/watch?v=wRXZY-wY8b0&t=311s
https://www.youtube.com/watch?v=bXDPx7Vp8GI&t=37s
Finasteride and gyno
https://www.youtube.com/watch?v=n2NGf3vzWFI&t=246s
Will finasteride shrink your penis:
https://www.youtube.com/watch?v=M7ToUtnB5e4&t=783
5ARIs and insulin resistance, diabetes
https://www.youtube.com/watch?v=2KxqUzctcVQ5ARIs and Blood Pressure & Heart Disease
https://www.youtube.com/watch?v=UxcqZO3F6kA&t=2s
Truth about dutasteride’s side-effects
https://youtu.be/5Pi0aczc8SI
All the 5AR isoenzymes:
https://youtu.be/Tzu_yWBR_rU
5ARIs and prostate cancer:
https://youtu.be/woHF0bvOAow
Why going bald can kill you:
https://youtu.be/rWM9fYHWoyU?si=vklpE6K5chVlcdbV
Bludflow and hair loss
https://youtu.be/X5tVmX8mIF4
https://youtu.be/icSupaq9hBA
https://youtu.be/yr-Atg3YFVg
Sources:
1. Imperato-McGinley J, Guerrero L, Gautier T, Peterson RE. Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science. 1974;186(4170):1213-1215. doi:10.1126/science.186.4170.1213
2. Barud W, Palusiński R, Makaruk B, Hanzlik J. Dihydrotestosterone treatment in men with coronary artery disease. I. Influence on sex hormones, lipid profile, insulin resistance and fibrinogen. Ann Univ Mariae Curie Sklodowska Med. 2003;58(2):241-246.
3. Bortolato M, Frau R, Orrù M, et al. Antipsychotic-Like Properties of 5-α-Reductase Inhibitors. Neuropsychopharmacol. 2008;33(13):3146-3156. doi:10.1038/npp.2008.39
4. Andriole GL, Bostwick DG, Brawley OW, et al. Effect of Dutasteride on the Risk of Prostate Cancer. New England Journal of Medicine. 2010;362(13):1192-1202. doi:10.1056/NEJMoa0908127
5. Mysore V. Finasteride and sexual side effects. Indian Dermatol Online J. 2012;3(1):62-65. doi:10.4103/2229-5178.93496
6. Beggs LA, Yarrow JF, Conover CF, et al. Testosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone. Am J Physiol Endocrinol Metab. 2014;307(5):E456-461. doi:10.1152/ajpendo.00184.2014
7. Upreti R, Hughes KA, Livingstone DEW, et al. 5α-reductase type 1 modulates insulin sensitivity in men. J Clin Endocrinol Metab. 2014;99(8):E1397-1406. doi:10.1210/jc.2014-1395
8. Joyce KE, Biggs ML, Djoussé L, et al. Testosterone, Dihydrotestosterone, Sex Hormone–Binding Globulin, and Incident Diabetes Among Older Men: The Cardiovascular Health Study. J Clin Endocrinol Metab. 2016;102(1):33-39. doi:10.1210/jc.2016-2623
9. Swerdloff RS, Dudley RE, Page ST, Wang C, Salameh WA. Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels. Endocrine Reviews. 2017;38(3):220-254. doi:10.1210/er.2016-1067
10. Da Silva MHA, Costa WS, Sampaio FJB, De Souza DB. The corpus cavernosum after treatment with dutasteride or finasteride: A histomorphometric study in a benign prostatic hyperplasia rodent model. Asian J Androl. 2018;20(5):505-510. doi:10.4103/aja.aja_28_18
11. Goodman PJ, Tangen CM, Darke AK, et al. Long-Term Effects of Finasteride on Prostate Cancer Mortality. New England Journal of Medicine. 2019;380(4):393-394. doi:10.1056/NEJMc1809961
12. Wei L, Lai ECC, Kao-Yang YH, Walker BR, MacDonald TM, Andrew R. Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study. BMJ. 2019;365:l1204. doi:10.1136/bmj.l1204
13. Chen X, Liu B, Li Y, et al. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture. Frontiers in Pharmacology. 2020;10. Accessed August 29, 2023. https://www.frontiersin.org/articles/10.3389/fphar.2019.01528
14. Round P, Das S, Wu TS, Wähälä K, Van Petegem F, Hammond GL. Molecular interactions between sex hormone–binding globulin and nonsteroidal ligands that enhance androgen activity. J Biol Chem. 2020;295(5):1202-1211. doi:10.1074/jbc.RA119.011051

source

25 thoughts on “The Ultimate Guide to Men's Hormones – TIER LIST (DHT is a trash hormone part VIII)”

  2. Hey Kevin i had a thought today i was curious if you would have any insight into it.

    So ive taken fin topical and oral and even at .25mg every other day i had severe sexual sides. I cant seem to tolerate dropping my DHT without feeling absolute trash.

    I rememeber hearing that most of the DHT that js problematic for follicles is DHT that is actually made ON SIGHT in the follicle.
    Unfortunately Even if you use something like topical finasteride, it inevitably goes systemic and still causes brutal side effects for some people such as myself.

    So my thought was this and perhaps you can let me know if this is in the realm of possibility. What if somebody used a potent topical five alpha reductase inhibitor such as topical DUT or FIN and then supplemented exogenously with DHT.

    What if you did something to elevate the systemic levels of your DHT while nuking it at the follicular site with the topical. I have never once heard this mentioned or discussed anywhere, but if systemic DHT levels were held in a normal range, could that prevent the sexual side effects while also enabling the use the topicals to nuke DHT at the follicular level?

    Reply

  4. random question: Lets say i have hair shedding from minoxidil after stopping for one month, then go back on treatment. How long would it take for those hairs to return after starting again? assuming it's just causing general hair shed and not all from androgenic alopecia.

    Reply

  7. Hey Kevin, I have a question. When applying minoxidil, do I have to rub it in, or can I just let it sit on my scalp like I usually do? I’m trying to maximize the results of the temples of my hairline.

    Reply

  9. Hello Kevin. I'm on Finastride for 11 months I have used 1 mg every alternative day for initial 6 months and then after 20 days break I started on 0.5 mg every day.. It's been 11 months but it ain't helping my hairloss. I have diffuse thinning and temple recession and it continues to progress. What can I do please help this choom 🥲

    Reply

  10. Can you talk about what causes permanent hair loss. The hair loss model has been explained a lot but I don’t get why Fin doesn’t regrow the scalp fully. I’ve heard that scar tissue forms but not sure if it’s true for younger people.

    There’s a Reddit post about Cyanidin 3-O-arabinoside speculating about pattern baldness ending up being the same as general aging, which is cellular senescence.

    Besides understanding what causes permanent loss. I guess it’d be nice to also know how DHT causes hair loss. We know it causes it but I literally saw a model where DHT was blocking and shrinking hairs physically, like it was displayed as a physical plug lol. Don’t think that’s how it works.

    Reply

  13. Have you done any videos on the possible connections between creatine use and hairloss? I started lifting and taking creatine (monohydrate) and about a month in, I experienced hair loss like nothing I've ever experienced before or since. I had long hair at the time, so it was very noticeable and overt. I've seen a lot of other guys mention similar. But the scientific evidence so far, is somewhat weak.

    Reply

  18. Hey Kev! I'm using Dutasteride 0.5mg EOD for hairloss and it's working really nice so far, but the thing is since it's every other day sometimes i forget if i took it the previous day or not. I wanted to know if it would be fine to use every monday, wednesday and friday and not use it on the weekends so that way i'm always consistent with it and don't have to worry if i forgot to took it, is it fine to use it this way since it has a long half life or would I be losing some of it's efficacy on the long run?

    Reply

  22. For the Phase III trial of Androgenetic alopecia(Long-term safety) in China, we finished first patient enrollment on 19 July. A total of 270 male and female patients will be enrolled and the treatment period is 52 weeks.

    This is an email I got from Kintor, thoughts?

    Reply

  23. Hi Kevin I have saved my hair with dutasteride and minoxidil !! But I want to start creatine .. if I take it 5g a day will have any impact on my hair ? Have you ever took creatine ?

    Reply

  24. iam taking fin 4 times a week for 2 months and nothing happens should i raise the dose and take it every day or should i wait also cant make my mind on taking minox not that i fear it but it will be kinda difficult if i get skin irritations coz at work its not allowed to wear hat or sth appreciate if i get a replie kevin ur doing good dawg

    Reply

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