The 4 Horsemen Of Death, Starting TRT, Longevity Drugs, Nootropics, Menopause And F1 – Peter Attia

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🕑 Timestamps:
0:00:00 – 0:10:40 – Epigenetics, Methylation, And The Hallmarks Of Aging
0:10:40 – 0:13:37 – If You Have A MTHFR Polymorphism, Will You Age Faster?
0:13:37 – 0:15:16 – Books That Have Dramatically Impacted Peter’s Life
0:15:16 – 0:19:02 – Peter’s Current Career Goals
0:19:02 – 0:22:42 – Sponsor: Eight Sleep (The Most Impactful Sleep Enhancing Device I Have Ever Used)
0:22:44 – 0:29:09 – AI And Developments In CT Angiography For The Early Detection Of Atherosclerosis
0:29:09 – 0:29:50 – Why Peter Typically Doesn’t Find Tests That Look For Early ASCVD Valuable
0:29:50 – 0:32:12 – Is There An APOB Level That Guarantees No Risk Of Atherosclerosis?
0:32:12 – 0:33:27 – For Those With Hypofunctioning PCSK9 And Extremely Low LDL-C, What Is Their Average Age Of Death, And What Are They Dying From?
0:33:27 – 0:35:06 – How Much Cholesterol Is Needed For Brain Development?
0:35:06 – 0:36:22 – How Lipid Managing Medications Work
0:36:22 – 0:41:16 – How Peter Evaluates The Best Strategy For Managing APOB For Each Patient
0:41:16 – 0:42:39 – Can You Trust Grocery Store Olive Oil?
0:42:39 – 0:44:09 – Is Olive Oil Healthier Than Eating Less?
0:44:09 – 0:46:15 – If You’re Thriving With Bad Lipids, What Should You Do?
0:46:15 – 0:47:56 – The Best Diet
0:47:56 – 0:49:34 – Are Statins Evil?
0:49:34 – 0:53:00 – Tests For Targeted Lipid Management
0:53:00 – 0:54:23 – Bempedoic Acid Vs. Statins
0:54:23 – 0:56:28 – The Reason Why Almost Nobody Should Be On Max Dose Statin Therapy
0:56:28 – 1:00:03 – Peter’s Multipronged Approach To Lipid Managing Pharmacology
1:00:03 – 1:05:22 – Sponsor: Marek Health (Preventive Medicine, HRT, & Rigorous Blood Work)
1:05:22 – 1:06:03 – The Biomarkers Peter’s Team Uses To Evaluate Liver Toxicity
1:06:03 – 1:06:45 – Causes Of NAFLD
1:06:45 – 1:08:57 – Which Statins Are The Most Likely To Cause Side Effects?
1:08:57 – 1:10:49 – The Price And Access To Repatha
1:10:49 – 1:14:04 – Will The CETP Inhibitor Obicetrapib Obliterate Atherosclerosis?
1:14:04 – 1:17:47 – Medications That Lower Lp(a)
1:17:47 – 1:20:13 – If Someone Has High Lp(a), But Excellent Metabolic Health, Can They Still Develop Premature Heart Disease?
1:20:13 – 1:21:21 – Are HDL-C Levels A Proxy For Insulin Sensitivity?
1:21:21 – 1:25:01 – The Insidious Effects Of Genetically High Lp(a)
1:25:01 – 1:26:50 – The Reason Why We Develop Plaque In Arteries, But Not Veins
1:26:50 – 1:27:33 – Maintain ≤ 120/80 Blood Pressure To Smash Your Risk Of Heart Disease And Dementia
1:27:33 – 1:28:34 – Is Lower Than 120/80 Better?
1:28:34 – 1:31:49 – How To Fix High Blood Pressure
1:31:49 – 1:34:12 – DEXA Scans And What A “Good” FFMI Is
1:34:12 – 1:36:24 – Is There Any Way To Verify Endothelial Damage?
1:36:24 – 1:38:16 – How Helpful Is A CT Angiogram?
1:38:16 – 1:40:06 – Can You Accurately Detect Plaque Accumulation In Yearly Intervals With CT Angiography?
1:40:06 – 1:43:47 – Why You Can Have No Detectable Inflammation In Bloodwork, But Still Develop Raging Atherosclerosis
1:43:47 – 1:51:24 – Why Peter Is Starting HRT, And What His Protocol Will Be
1:51:24 – 2:00:47 – Women’s Birth Control Options
2:00:47 – 2:05:42 – When Should Women Start HRT?
2:05:42 – 2:11:41 – Optimizing Women’s HRT Protocols
2:11:41 – 2:14:55 – Why Women Have 2x Higher Lifetime Risk Of Alzheimer’s Than Men
2:14:55 – 2:15:48 – Using Symptoms And FSH Levels As A Target
2:15:48 – 2:18:51 – The Prevalence Of Hypothyroidism
2:18:51 – 2:22:09 – When Should You Treat Inflammation With Supplements Or Medications?
2:22:09 – 2:24:48 – Will Cold Plunge Pre-Workout Inhibit Muscle Growth?
2:24:48 – 2:25:43 – Cold Plunge Increases Dopamine As Much As Coke!?
2:25:43 – 2:30:54 – Peter’s Use Of Modafinil, Nicotine, Caffeine, And What He Thinks The Best Nootropic Is
2:30:54 – 2:33:29 – How To Properly Dose Omega-3 Supplements
2:33:29 – 2:38:30 – Sponsor: Gorilla Mind (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations)
2:38:30 – 2:42:33 – What Actually Causes Brain Fog?
2:42:33 – 2:46:36 – How Obesity Impacts Mitochondrial Function
2:46:36 – 2:48:38 – Ideal Daily Magnesium Intake
2:48:38 – 2:51:42 – What Are The Most Important Sleep Metrics To Track?
2:51:42 – 3:22:27 – F1 Talk
3:22:27 – 3:30:26 – Reconnecting Peter Attia With His Long-Lost Obsession… Tearing Phone Books!
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40 thoughts on “The 4 Horsemen Of Death, Starting TRT, Longevity Drugs, Nootropics, Menopause And F1 – Peter Attia”

  8. 44:11 Here it is. The advice you would get from your typical drug pushing doctor. Stay on the diet that’s causing your lipids to go haywire, we can always get you on a statin to sort it out. I always knew this hack was in bed with big Pharma but this line confirms it.

    Reply

  9. Prioritizing lipid-lowering medicine over diet and so metabolic health is so sad to hear in 2024. This autistic fixation on fixing single blood markers instead of helping patients achieve positive long term health outcomes… what a waste of talent.
    Oh boy when I go running I always pick a podcast and stick to it all along the way but I had to make an exception with this one after an hour.

    Reply

  23. Derek, you need to have on a guest that is the pinnacle of women’s health and hormones. Maybe you have, and could you link the episode? I know your demographic is men, but we all clip it and send it to the women in our lives. Preferably a women guest, they hate hearing from a man what they should do. 😁

    Reply

  24. For those of us who used tren for about a decade, tren replacement therapy should be a thing. I miss that stuff. Nothing works better but now that I’m in my 50’s, I can’t rationalize using it anymore. Just low dose test and occasional “blasting” with 250 mg per week with deca. So that’s a 500 mg stack. About a quarter of what I used to use.😢

    Reply

  31. Hey Derek. Great work as usual. Please consider setting up a Marek health clinic in the UK. If made competitive with other companies pricing I can pretty much guarantee it will be highly successful. Not that there are many companies over here that do what your guys do, to the standard you guys do it.

    I suspect you have certain hurdles holding you back from making the expansion, and maybe the regulations over in the UK don't allow a smooth/easy process? Any information on the subject would be highly appreciated, if it's something you have considered. Thanks.

    Reply

  34. 2:47 PM. Sitting in the park shirtless, veins looking like Google Maps. Chugging from my jug labeled ‘ENGINE FLUID’ while staring down a squirrel that dared to get too close to my chicken filet to go. Now i kinda want his stash off nuts for the oils. Some kid walked by and asked his mom, ‘Why is that man so angry?’ I’M NOT ANGRY, LITTLE TIMMY, THIS IS JUST HOW PEAK PERFORMANCE LOOKS. She smelled nice tho. A jogger passed and muttered ‘steroids,’ so I immediately trew a stone hitting him in the calf and started doing push-ups on the grass just to assert dominance. Grass stains? Extra fiber it you ask me! I’m powered by tren and zero regard for social norms. Currently plotting how to deadlift this park bench, but it has bolts. I love Mondays. At least i think its Monday, it should always be Mondays, sepperate the strong from the weak.

    Reply

  35. hey derrick been following for so long now i’d love for you to rate my current physical condition always been built well i keep getting told i look great but i don’t believe i struggle with confidence and id love for you to rate my genetics and see how im doing if you’d ever have chance i have autistic spectrum condition and have eating disorders but managed to build quite a bit of muscle

    Reply

  38. I'm not even a Hamilton fan, but not having him in your top 5 f1 drivers is crazy lol. Statistics have to matter or what are they driving for. Won a championship at 2 separate manufacturers, most wins ever, most poles. You can dislike the style, but the dude completed everything in F1 with some solid teamates to compete with. (Also the F1 talk shows this was made a long time ago lol)

    Reply

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