Episode 58: Jeffrey Su: Semaglutatide to the Rescue for Contest Prep Hunger
In this episode of J3 University, Luke and I are joined by coach Jeffrey Su of First Call Out Fitness. Jeffrey takes us through the application of the popular diabetic and weight loss drug Semaglutatide. With many physique competitors using it for its hunger suppressing effects we look into the application of the drug for this and Jeffrey gives his opinion on how or when this should or should not be applied.
Timestamps
Introducing Jeffrey Su – 00:00:14
Background of GLP1RA – 00:01:29
Dysregulation of Hormones and Receptor Site Desensitization – 00:05:52
Deploying GLP1RA for Eating disorders? – 00:11:48
Negatives to GLP1RA – 00:17:05
Oral and Injectable – 00:19:54
Application for bodybuilding population – 00:21:21
Managing clients post show – 00:30:12
Other areas of application – 00:33:40
Where to find Jeffrey Su – 00:44:42
@firstcalloutfitness
www.firstcalloutfitness.com
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Tirzapetide acts on GIP more than GLP whereas Semaglutide works just on GLP.
Jeff is a wealth of knowledge but just wanted to clarify starting dosing and titration on semaglutide. To avoid as many starting side effects as possible start at 250mcgs of injectable Semaglutide for 4 weeks and then if side effects are manageable or non existent move to 500mcgs for at least 2 weeks. If side effects are manageable and you need more glucose control up to 1mg. If more is needed you can move to 1.7mgs after a minimum of 2 weeks and with a final dose of 2.4mgs per week if necessary. This is per the studies done.
As someone who has had to battle with really severe acid reflux, I'm really surprised so many Bodybuilders are using this so nilly-willy. The decreased gastric emptying makes all alarm bells in my head go off, and Jeffrey himself stated how it can be a very negative aspect of the drug. I have the feeling this drug isn't getting the respect it deserves in the bodybuilding community, it just gets thrown in for cutting (and wit the typical "more is better" mantra that bodybuilders have, hehe).
The appetite reduction is basically a side effect, not really the reason it gets used in clinical applications.
First comment got deleted. 1mg is NOT a starting point even for people with diabetes is .25mg a week.
Also I am surprised to hear all of you so anti this for last few weeks of prep yet the sad alternate reality is competitors abusing any and all stims they can get their hands on and even harsh oral steroids to crush their appetite. It seems a low dose at a low interval if this is a possible alternative